Phthalic Anhydride → HCID 10028212, compound

Participants

Reaction Steps

A solution of 566 mg (1.69 mmole) of 4-(4-aminobenzyl)-3-n-butyl-5-(carbomethoxymethylthio)-4H-1,2,4-triazole in 15 ml of dry tetrahydrofuran (THF) was treated with 250 mg (1.69 mmole) of phthalic anhydride dissolved in 2 ml of dry THF. The resulting solution was stirred overnight at room temperature in a stoppered flask. The solid which had precipitated was collected on a filter and washed with ether to yield (after vacuum-drying at 30° C.) 629 mg (77%) of a white solid, mp 161°-162° C., homogeneous by TLC in 90:10:1CH2Cl2 --MeOH-AcOH; mass spectrum (FAB) m/e 483 (M+1)+.

Provenance & Evidence