Azido(trimethyl)stannane → HCID 178441963, compound

Participants

Reaction Steps

The title compound was prepared from 3-n-butyl-5-(4-chlorobenzylsulfonyl)-4-[(2'-cyanobiphenyl- 4-yl)methyl]-4H-1,2,4-triazole (Step A) according to the procedure of Example 15, Step E, except that 3.5 equivalents of trimethyltin azide were added at the start, and the column was eluted with a gradient of 0-10% methanol in CH2Cl2. The product was obtained in 17% yield as a glass, which was transformed to a powder upon scraping: mp 180°-182° C. dec.; homogeneous by TLC in 4:1CH2Cl2 --MeOH; mass spectrum (FAB) m/e 548 (M+1)+.

Provenance & Evidence