1-Chloro-4-(chloromethyl)benzene → HCID 10070562, compound

HRID 1742111Notes

Reaction equation

HRID 1742111 reaction equation
[CH2:1]([C:5]1[N:6]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][CH:13]=2)[C:7](=[S:10])[NH:8][N:9]=1)[CH2:2][CH2:3][CH3:4].[Cl:21][C:22]1[CH:29]=[CH:28][C:25]([CH2:26]Cl)=[CH:24][CH:23]=1>>[CH2:1]([C:5]1[N:6]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][CH:13]=2)[C:7]([S:10][CH2:26][C:25]2[CH:28]=[CH:29][C:22]([Cl:21])=[CH:23][CH:24]=2)=[N:8][N:9]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 77231-Chloro-4-(chloromethyl)benzeneHCID 10356994HCID 10356994, compound

Product 1

HCID 10070562HCID 10070562, compoundYield 90%

Procedure

Reaction of 5-n-butyl-2,4-dihydro-4-(4-nitrobenzyl)-3H-1,2,4-triazole-3-thione with 4-chlorobenzyl chloride according to the procedure of Example 4, Step A (with reaction time shortened to 4.5 hours) gave a 90% yield of the title compound as an oil, homogeneous by TLC in 19:1 CH2Cl2 --MeOH; mass spectrum (FAB m/e 417 (M+1)+.

Workup

  1. customto the procedure of Example 4, Step A (with reaction time shortened to 4.5 hours)

Sources & evidence

ORD record
ord-83c34fe599d9439eaf5c1a05f57b6f12
Source dataset
uspto-grants-1994_08
Patent number
US05336778

Reaction notes

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