HCID 57404210, compound → HCID 131718642, compound

Participants

Reaction Steps

[1-(Benzyloxycarbonyl)amino-3-methybutyl(methoxy)phosphinyl]acetic acid tert-butyl ester, prepared by the literature procedure: Bartlett, P. A.; Kezer, W. B.; J. Am. Chem. Soc. , 106, 4282 (1984), (357 mg, 0.86 mmol) was dissolved in MeOH (11 mL) and hydrogenolyzed under H2 using 10% Pd/C (84 mg) for approximately one hour. The catalyst was removed by filtration and the solvent removed under reduced pressure to give the title product as an oil (230 mg, 100%). The 300 MHz 1H NMR spectrum was found to be consistent with the proposed structure.

Provenance & Evidence