Ethanol → HCID 22619924, compound

Participants

Reaction Steps

A mixture of pyridine-4-carboxaldehyde (26.78 g, 0.25 mole) and ethyl amine (32.2 g of a 70% water solution, 0.5 mole) were stirred for 20 min. Cyclohexane (250 ml) was added and the mixture was refluxed for 3 hrs under a Dean-Stark trap. The mixture was then concentrated in vacuo. Ethanol (250 ml) and sodium borohydride (thirteen 0.4 g tablets, 0.13 mole) were then added to the residue and mixture was stirred for 18 hrs. The mixture was concentrated in vacuo and the residue was dissolved in methylene chloride (250 ml) and filtered. The filtrate was concentrated in vacuo to give the product, N-ethyl-4-aminomethylpyridine (26.92 g, 79% which was taken on without purification.

Provenance & Evidence