1,1'-Carbonyldiimidazole → HCID 19008874, compound

Participants

Reaction Steps

A solution of 2-norbornaneacetic acid (1.54 g, 10 mmole) and 1,1'-carbonyldiimidazole (1.62 g, 10 mmole) in methylene chloride (35 ml) was stirred for 15 min and then 1-(4-pyrimidinyl]-4-piperidinemethaneamine (V; 1.92 g, 10 mmole) was added. After stirring for 18 hrs the solution was diluted with methylene chloride (100 ml) and extracted with water (3×30 ml) and saturated sodium carbonate (30 ml). The methylene chloride layer was dried over magnesium sulfate and concentrated in vacuo to give a white solid. The crude product was recrystallized from a mixture of ethyl acetate (15 ml) and hexane (15 ml) to give the formula I product as a white powder (2.59 g, 79%, mp: 121°-126°).

Provenance & Evidence