Butyl bromide → HCID 19008984, compound

Participants

Reaction Steps

Excess 1-bromobutane was added to a mixture of 0.9 g of 4-[3-(4-hydroxyphenyl)propyl]pyridine in 10 mL of 2N NaOH, and the mixture was refluxed for several hours. Then the mixture was cooled and the pH adjusted to 10. The product was extracted with CH2Cl2. The CH2Cl2 layer was then separated, washed with fresh water, filtered through phase separating paper, and concentrated. The residue was adsorbed onto silica gel and chromatographed over silica gel eluting with CH2Cl2 >15% EtOAc/CH2Cl2. Yield 0.45 g.

Provenance & Evidence