Tetrahydrofuran → HCID 19763654, compound

Participants

Reaction Steps

To a solution of 4'-[[5,7-dimethyl-2-ethyl-3H-imidazo [4,5-b]pyridin-3-yl]methyl][1,1'-biphenyl-2-yl]carboxylic acid hydrazide (400 mg, 1 mmol) and triethylamine (130 mg, 1.3 mmol) in THF (20 mL) was added carbonyldiimidazole (275 mg, 1.7 mmol) at 0° C. The reaction mixture was stirred at room temperature overnight and the solvent was evaporated. The residue was dissolved in water and the solution was adjusted to pH 3 by the addition of 1N HCl. The resulting precipitate was collected by filtration and dried under vacuum to give 5-[4'-[[5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridin-3-yl]methyl][1,1'-biphenyl-2-yl]-1,3,4-oxadiazol-2[3H]-one (0.35 g, 81%) as a partial hydrate, mp 210°-212° C.

Provenance & Evidence