Hydrazine → HCID 67821539, compound

HRID 1742225Notes

Reaction equation

C[O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[CH:16]=[CH:15][C:14]([CH2:17][N:18]2[C:22]([CH2:23][O:24][Si:25]([C:28]([CH3:31])([CH3:30])[CH3:29])([CH3:27])[CH3:26])=[C:21]([Cl:32])[N:20]=[C:19]2[CH2:33][CH2:34][CH2:35][CH3:36])=[CH:13][CH:12]=1)=O.[NH2:37][NH2:38]>>[CH2:33]([C:19]1[N:18]([CH2:17][C:14]2[CH:13]=[CH:12][C:11]([C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=3[C:3]([NH:37][NH2:38])=[O:2])=[CH:16][CH:15]=2)[C:22]([CH2:23][O:24][Si:25]([C:28]([CH3:29])([CH3:30])[CH3:31])([CH3:26])[CH3:27])=[C:21]([Cl:32])[N:20]=1)[CH2:34][CH2:35][CH3:36]

Participants

Reactant 2

HCID 9321Hydrazine

HCID 54201453HCID 54201453, compound

Product 1

HCID 67821539HCID 67821539, compoundYield 60%

Procedure

According to the procedure of Example 2, 4'-[[2-butyl-4-chloro-5-(t-butyldimethylsilyloxymethyl)-1H-imidazol-1-yl]methyl][1,1'-biphenyl-2-yl]carboxylic acid methyl ester was treated with hydrazine to give 4'-[[2-butyl-4-chloro-5-(t-butyldimethylsilyloxymethyl)-1H-imidazol-1-yl]methyl][1,1'-biphenyl-2-yl]carboxylic acid hydrazide (60%) .

Sources & evidence

ORD record: ord-9096d63ef8734baebaf1c5b523990b15
Source dataset: uspto-grants-1994_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05338737

Reaction notes

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