Boron tribromide → HCID 23361289, compound

HRID 1742257Notes

Reaction equation

HRID 1742257 reaction equation
[C:1]([N:9]1[CH2:13][CH2:12][CH2:11][CH:10]1[C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([O:20]C)[CH:15]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.B(Br)(Br)Br>C(Cl)(Cl)Cl>[C:1]([N:9]1[CH2:13][CH2:12][CH2:11][CH:10]1[C:14]1[CH:15]=[C:16]([OH:20])[CH:17]=[CH:18][CH:19]=1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 23361287HCID 23361287, compound

Product 1

HCID 23361289HCID 23361289, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of 1-benzoyl-2-(3-methoxyphenyl)pyrrolidine (1.0 g) in chloroform (40 ml) was added boron tribromide (99%, 1.0 ml) at -10° C., under nitrogen. The cooling bath was removed after 15 mins, and the reaction mixture was allowed to warm to ambient temperature. Crushed ice was added to the reaction mixture followed by 5:1-chloroform/2-propanol. The layers were separated, and the aqueous phase was extracted with 5:1-chloroform/2-propanol (2 times). The combined organic extracts were washed with saturated sodium bicarbonate solution, dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated. The residue was crystallized from dichloromethane/petroleum ether to give 0.89 g (94 %) of product. Recrystallization from 2-propanol/methanol gave the analytical sample, mp 167°-169° C.

Workup

  1. customThe cooling bath was removed after 15 mins
  2. additionCrushed ice was added to the reaction mixture
  3. customThe layers were separated
  4. extractionthe aqueous phase was extracted with 5
  5. washThe combined organic extracts were washed with saturated sodium bicarbonate solution
  6. dry with materialdried over anhydrous sodium sulfate
  7. filtrationfiltered
  8. concentrationthe filtrate was concentrated
  9. customThe residue was crystallized from dichloromethane/petroleum ether

Sources & evidence

ORD record
ord-fb40dc1b94d54ec399d76dfaad1c4a62
Source dataset
uspto-grants-1994_08
Patent number
US05338739

Reaction notes

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