HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 178468747, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Chloro-1-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethanone | HCID 14726533 | — |
| Reactant | 4-Amidinobenzoic acid ethyl ester hydrochloride | HCID 67790291 | — |
| Product | HCID 178468747 | HCID 178468747 | — |
Reaction Steps
2.6 g (10 millimoles) of 6-chloroacetyl-1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalene (for preparation see Example 28), 2.1 g (10 millimoles) of 4-carbethoxybenzamidinium chloride and 5 g of potassium carbonate in 100 ml of dimethylformamide were refluxed for 1 hour. After cooling, the mixture was poured onto water and stirred for 10 minutes, and the precipitate formed was filtered off under suction. Purification by column chromatography (silica gel; 9:1 n-heptane/ethyl acetate) gave 0.3 g of the title compound of melting point 186°-188° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05338749 |
| Source dataset | uspto-grants-1994_08 |
| ORD ID | ord-725a781efbd04eb5bd1084b57af76677 |
| Source note | uspto-grants-1994_08 |