Sodium Hydroxide → HCID 19009185, compound

HRID 1742443Notes

Reaction equation

HRID 1742443 reaction equation
[N:1]1([C:10]([CH2:16][CH:17]=[CH2:18])([CH2:13][CH:14]=[CH2:15])[C:11]#[N:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][N:8]=2)[CH:3]=[CH:2]1.[H-].[H-].[H-].[H-].[Li+].[Al+3].[OH-].[Na+]>CCOCC>[N:1]1([C:10]([CH2:16][CH:17]=[CH2:18])([CH2:13][CH:14]=[CH2:15])[CH2:11][NH2:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][N:8]=2)[CH:3]=[CH:2]1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 19009181HCID 19009181, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 19009185HCID 19009185, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

4 g of the compound of stage 1, dissolved in 40 ml of ether, are added to a suspension of 0.96 g (0.0253 tool) of LiAlH4 in 100 ml of ether. The mixture is heated to reflux for 3 hours. It is cooled and 5% sodium hydroxide is added at room temperature, settling is allowed to take place, the aqueous phase is washed with ether, the ether phases are dried over sodium sulphate and filtered and the filtrate is evaporated. A liquid compound is thereby obtained.

Workup

  1. temperatureThe mixture is heated
  2. temperatureto reflux for 3 hours
  3. temperatureIt is cooled
  4. washthe aqueous phase is washed with ether
  5. dry with materialthe ether phases are dried over sodium sulphate
  6. filtrationfiltered
  7. customthe filtrate is evaporated
  8. customA liquid compound is thereby obtained

Sources & evidence

ORD record
ord-c7669fc90bf149169b12d9d335649056
Source dataset
uspto-grants-1994_08
Patent number
US05338849

Reaction notes

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