Water → HCID 19009180, compound

Participants

Reaction Steps

0.45 g of sodium borohydride is added in small portions at between 20° and 25° C. to a solution of 4.6 g of compound of stage 1 above in 80 ml of methanol. The mixture is stirred for 2 hours, 2 ml of water are then added, the resulting mixture is evaporated, the residue is taken up with dichloromethane, the dichloromethane solution is washed with water, dried over Na2SO4, filtered and evaporated and the residue is chromatographed on silica gel(eluant: ethyl acetate/hexane, 8:2).

Provenance & Evidence