Water → HCID 19009260, compound

Participants

Reaction Steps

20 ml of a 1.0M hexane solution of diisobutylaluminum hydride were added at -70° C. to a solution of 3.36 g of 4-(1,4-dimethoxy-2-naphthyl)butyronitrile [prepared as described in step (a) above] in 100 ml of dry methylene chloride, and the resulting mixture was stirred for 2 hours. At the end of this time, water was added to the reaction mixture, and the insoluble materials were filtered off with the aid of a Celite (trade name) filter aid. The methylene chloride layer which separated was dried over anhydrous sodium sulfate, and the solvent was removed by distillation under reduced pressure, to give 2.96 g of the title compound as a colorless oil.

Provenance & Evidence