HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Isocyanate → 1-{1,2-Dimethyl-1-[(p-tolylsulfonyl)carbamoyl]propyl}-3-methylurea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Isocyanate | HCID 12228 | — |
| Reactant | 2-Amino-2,3-dimethyl-N-(p-tolylsulfonyl)butyramide hydrochloride | HCID 20089870 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-{1,2-Dimethyl-1-[(p-tolylsulfonyl)carbamoyl]propyl}-3-methylurea | HCID 14695762 | — |
Reaction Conditions
| Temperature | -30 °C |
|---|
Reaction Steps
A solution of 2-amino-2,3-dimethyl-N-(p-tolylsulfonyl)butyramide hydrochloride (5 g, 15.58 mmols) dissolved in 50 mL of DMF under nitrogen is cooled to -30° C. Then 10 mL of methyl isocyanate in 10 mL of THF is added at such a rate that temperature is maintained at -30° C., and the reaction mixture is allowed to stir for two hours at -30° C. and then for 16 hours at room temperature.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05338883 |
| Source dataset | uspto-grants-1994_08 |
| ORD ID | ord-414962464b4f4352ae4cb7caf97a5ec0 |
| Source note | uspto-grants-1994_08 |