Formaldehyde → 3-Phenyl-5-{2-(1-pyrrolidinylmethyl)-3-methylbutyryl}isoxazole

Participants

Reaction Steps

From 1.5 g (6.6 mmol) of 3-phenyl-5-(3-methyl-butyryl)isoxazole prepared above in the procedure (2), 0.84 g (7.9 mmol) of piperidine hydrochloride, and 0.26 g (8.7 mmol) of paraformaldehyde, the free base of 3-phenyl-5-{2-(1-pyrrolidinylmethyl)-3-methylbutyryl}-isoxazole was obtained as crystals in a manner similar to Example 28. Analytical results of the crystals obtained: Yield: 0.7 g (34.3%). Melting point: 77°-79° C.

Provenance & Evidence