HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-dihydro-2H-pyran → 3-Butyryl-1,2-benzisoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| Reactant | Ethylmalonic acid | HCID 11756 | — |
| Reactant | 1,2-Benzoxazole-3-carboxylic acid | HCID 2735445 | — |
| Product | 3-Butyryl-1,2-benzisoxazole | HCID 19976921 | — |
Reaction Steps
Using 3.7 g (23 retool) of 3-carboxy-1,2-benzisoxazole prepared in accordance with a known process [J. Amer. Chem. Soc., 97, 7305 (1975)], 3.34 g (25 mmol) of ethylmalonic acid and 6.4 g of 3,4-dihydropyran, 3-butyryl-1,2-benzisoxazole was obtained as colorless crystals by similar treatment to Example 28-(4). Analytical results of the crystals obtained: Yield: 3.5 g (85%). Melting point: 33°-35° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05338857 |
| Source dataset | uspto-grants-1994_08 |
| ORD ID | ord-7888a99fe8564a4bb023dfcb1233dc99 |
| Source note | uspto-grants-1994_08 |