Methyl Methacrylate → Loxoprofen Sodium

Participants

Reaction Conditions

Reaction Steps

To 60 l of water were added 1.0 kg of gelatin, 0.01 kg of sodium dodecylbenzenesulfonate and 0.05 kg of ammonium persulfate. While stirring this solution at a solution temperature of 60° C., a mixture of (a) 3.0 kg of styrene, (b) 3.0 kg of methyl methacrylate and (c) 3.2 kg of ethyl acrylate, and 0.8 kg of sodium 2-acrylamido-2-methylpropanesulfonate were added in a nitrogen atmosphere over a 1-hour period, followed by stirring for 1.5 hours. Then after the residual monomer was removed by steam distillation for 1 hour, the mixture was cooled to room temperature and then adjusted to pH 6.0 with ammonia. Water was added to the resulting latex liquid to make a total quantity of 75 kg. A monodispersed latex having an average grain size of 0.1 μm was thus obtained.

Provenance & Evidence