Sodium Carbonate → HCID 15222897, compound

Participants

Reaction Steps

A mixture of methyl 7-acetylamino-10-oxo-10H-pyridazino [6, 1-b]-quinazoline-2-carboxylate (0.38 g, 1.22 mmol, Example 4, Step B) and 0.5M sodium carbonate solution (6.0 mL, 3.0 mmol), Example 4, Step B) and 0.5M sodium carbonate solution (6.0 mL, 3.0 mmol) in 100 mL of THF:ethanol:water (1:1:2) was gently refluxed for 3 h. The resultant solution was filtered through a pad of Celite, concentrated, redissolved into water, acidified to a pH~ 1.5-2.0 with 10% hydrochloric acid and cooled. Solid formed, the mixture was filtered and washed with water, acetone and diethyl ether to give the titled compound as a dark yellow solid, mp 272°-275° C. dec

Provenance & Evidence