(1,1-Dimethylethyl)-5-hydroxy-2-pyrimidine carboxylic acid methyl ester → 4,6-Ditert-butyl-5-hydroxy-2-pyrimidinecarboxylic acid

Participants

Reaction Steps

A solution of 4,6-his (1,1-dimethylethyl)-5-hydroxy-2-pyrimidine carboxylic acid methyl ester (500 mg) in 1N NaOH (50 mL) is heated at reflux for 1 hour. The reaction mixture is cooled, filtered, and acidified to pH 4 with 1N HCl. The resulting precipitate is collected by filtration and dried at room temperature under vacuum to give pure 4,6-bis (1,1-dimethylethyl)-5-hydroxy-2-pyrimidine carboxylic acid (430 mg); mp 200° C. dec.

Provenance & Evidence