GR 127935 → HCID 10600871, compound

Participants

Reaction Steps

A mixture of the product of Example 1 (91 mg) and pyridine hydrochloride (2 g) was heated to 180°-190° for 8 h. Sodium bicarbonate (8%; 30 ml) was added and the mixture extracted with dichloromethane (2×25 ml). The dried extracts were evaporated to give a dark oil. This material was chromatographed on silica gel (Merck 7729, 10 g) eluting with System A (200:8:1) to give the title compound as a colourless foam (27 mg).

Provenance & Evidence