Potassium Carbonate → HCID 18654454, compound

Participants

Reaction Steps

A mixture containing 3-(S)-(1-carbamoyl-1,1-diphenylmethyl)pyrrolidine (0.1 g--see Preparation 10B), 4-hydroxyphenethyl bromide (0.072 g), anhydrous potassium carbonate (0.15 g) and acetonitrile (2 ml) was heated under reflux for 45 minutes. On cooling, the mixture was partitioned between dichloromethane (5 ml) and 10% aqueous potassium carbonate (10 ml). The layers were separated, and the aqueous layer was further extracted with dichloromethane (2×5 m]). The combined dichloromethane extracts were dried (MgSO4) and concentrated in vacuo to give a foam which was purified by column chromatography on silica eluting with dichloromethane containing methanol (5%). The product-containing fractions were combined and concentrated in vacuo to give the title compound as a colourless foam, yield 0.035 g.

Provenance & Evidence