HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → (S)-2,2-Diphenyl-2-(pyrrolidin-3-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | (2R,3R)-2,3-Dihydroxybutanedioic acid--2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide (1/1) | HCID 24968963 | — |
| Solvent | Water | HCID 962 | — |
| Product | (S)-2,2-Diphenyl-2-(pyrrolidin-3-yl)acetamide | HCID 13633758 | — |
Reaction Steps
3-(S)-(+)-(1-Carbamoyl-1,1-diphenylmethyl)pyrrolidine L-(+)-tartrate from part (A) (0.95 g) was dissolved in water (40 ml) and basified (pH 12) by the dropwise addition of 10% aqueous sodium hydroxide. The mixture was extracted with dichloromethane (2×50 ml), the extracts were combined, dried (Na2SO4), and concentrated in vacuo to give the title compound as a colourless foam, yield 0.64 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05340831 |
| Source dataset | uspto-grants-1994_08 |
| ORD ID | ord-dea218190ae748e0b45a088036f6d2af |
| Source note | uspto-grants-1994_08 |