Isoamyl Alcohol → HCID 19006814, compound

Participants

Reaction Conditions

Reaction Steps

49.5 g (0.45 mol) of sodium t-amylate are dissolved in 200 ml of isopentanol at 50° C., and 13 ml (0.11 mol) of trichloropyrimidine in 50 ml of isopentanol are added dropwise to this solution over the course of 30 minutes. After the mixture has been warmed at 50° C. for one hour, thin-layer chromatography shows that the mixture no longer contains any starting material. The solvent is removed on a rotary evaporator, and the residue is poured into 200 ml of water. The mixture is extracted three times with 150 ml of toluene in each case, and the organic phases are dried using MgSO4 and filtered. Removal of the solvent gives 37.5 g (98.7% of theory) of 2,4,6-tris(3-methylbut-1-oxy)pyrimidine.

Provenance & Evidence