HCID 13730806, compound → HCID 19005819, compound

Participants

Reaction Steps

To a solution of 2-(4-isopropyl-4-methyl-5-oxo-2 -imidazolin-2-yl)-6-nitro-3-quinolinecarboxylic acid (212 mg, 0,594 mmol) and methanol (100 mL), a 50 mg quantity of 10% palladium on carbon is added under argon. The mixture is allowed to shake under a hydrogen atmosphere (4 psi) for thirty minutes at room temperature, The catalyst is removed by filtration through diatomaceous earth and then the filtrate is concentrated in vacuo. The concentrate is partitioned between 100 mL portions of chloroform and water and the layers are separated. The organic layer is washed three times with water, dried over anhydrous sodium sulfate and concentrated in vacuo to give formula III 6-amino-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin2-yl)-3-quinolinecarboxylic acid as a yellow solid (170 mg). The purity of this material is determined by TLC on silica gel with chloroform, methanol and acetic acid (220:30:6) elution.

Provenance & Evidence