Sodium Dithionite → HCID 21800091, compound

Participants

Reaction Steps

Compound c (3.0 g, 11.4 mmol) was suspended in a mixture of 25 ml of water and 40 ml of ethanol. Twenty milliliters of aqueous solution of 6.9 g (40 mmol) of sodium hydrosulfite was added, and the resulting mixture was stirred at room temperature for 2.5 hours. The reaction mixture was extracted three times with 50 ml of chloroform. The organic layer was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by column chromatography (eluent: 3% methanol/chloroform) to give 2.40 g (yield: 84%) of Compound b as an amorphous substance.

Provenance & Evidence