Butyl iodide → HCID 11458539, compound

Participants

Reaction Conditions

Reaction Steps

To 200 ml of an N,N-dimethylformamide solution containing 15.7 g (0.100 mol) of methyl 3-aminothiophene-2-carboxylate and 15.2 g (0.110 mol) of potassium carbonate was added 34.1 ml (0.300 tool) of n-butyl iodide at 25° C., and the mixture was stirred at 120° C. for 10 hours. After cooling, the solvent was distilled off under reduced pressure, and 200 ml of ethyl acetate was added thereto, and then the inorganic salt was filtered off. The filtrate was concentrated also under reduced pressure. The resulting residue was purified by silica gel column chromatography to obtain 10.2 g (48%) of Compound (a-1).

Provenance & Evidence