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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1742848Generated: October 30, 2026

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-8-trifluoromethyl-3-quinolinecarboxylic acid → 7-[3-[2-(Aminomethyl)phenyl]-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-8-(trifluoromethyl)-3-quinolinecarboxylic acid

https://huagongshe.com/reaction/1742848

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-8-trifluoromethyl-3-quinolinecarboxylic acidHCID 14278830—
Reactant2-(3-Pyrrolidinyl)benzenemethanamineHCID 15288428—
Product7-[3-[2-(Aminomethyl)phenyl]-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-8-(trifluoromethyl)-3-quinolinecarboxylic acidHCID 15231290—

Reaction Steps

Starting from 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-8-trifluoromethyl-3-quinolinecarboxylic acid (1.00 g, 3.0 mmol) and 2-(3-pyrrolidinyl)benzenemethanamine, a procedure analogous to that given in Example 1 provided the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05342844
Source datasetuspto-grants-1994_08
ORD IDord-88ffea09cec5462c98f27c5225ff9a7b
Source noteuspto-grants-1994_08