反应详情

Iodomethane (1.62 g, 11.4 mmol) was added dropwise to a stirred suspension of 1-cyclopropyl-6-fluoro-1,4 -dihydro-4-oxo-7-[3-(3-pyridinyl)-1-pyrrolidinyl]-3-quinolinecarboxylic acid (0.30 g, 0.8 mmol) in acetonitrile (30 mL). The resulting mixture was heated at reflux for 2 hours. The suspension was then filtered, the solids were washed with acetonitrile and ether, and dried in vacuo at 40° C. to give the title compound (0.38 g, 88%) as a light yellow solid, mp 278°-280° C.

1. temperatureThe resulting mixture was heated
2. temperatureat reflux for 2 hours
3. filtrationThe suspension was then filtered
4. washthe solids were washed with acetonitrile and ether
5. customdried in vacuo at 40° C.