HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Indenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Cerium(III) chloride | HCID 24636 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 1H-inden-1-one | HCID 11815384 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | Indenol | HCID 316919 | 99% |
Reaction Steps
The indenone from Example 109 (0.5 g) is reduced with NaBH4 (0.05 g) and cerium chloride (0.5 g) in methanol (20 ml). The reaction is ended after 10 minutes and the reaction mixture is poured into water. The pH is taken to 5 by means of dilute HCl and the mixture is extracted with ethyl acetate. It is washed with water and the solvent is evaporated. Indenol (0.49 g; m.p. 134° C.) is obtained (yield: 99%; compound no. 110).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05342835 |
| Source dataset | uspto-grants-1994_08 |
| ORD ID | ord-cd9cf0ff7a204f888cf069744c378c51 |
| Source note | uspto-grants-1994_08 |