Water → HCID 19006082, compound

Participants

Reaction Steps

A mixture of the thiazole-benzoic acid XXIX (R=Ph: 1.0 g, 3.6 mM) and carbonyldiimidazole (0.9 g, 5.3 mM) in DMF (8 mL) was stirred for 30 min at room temperature. Diethylaminopropylamine was added to this mixture and the reaction was stirred for 2 hours, followed by the addition of water. The resulting suspension was extracted with several portions of ethyl acetate and the combined organic extracts were dried (MgSO4) and concentrated in vacuo. The residue was treated with hexane and oxalic acid to give the title compound as an oxalate salt: mp 115° C. MS: 394 (MH+). Anal. Calc'd for C23H27N3OS.C2H2O4.H2O: C, 59.86; H,6.23; N,8.38 Found: C, 60.20; H,6.16; N,8.80

Provenance & Evidence