O-Xylene → HCID 19006208, compound

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Reaction Steps

A mixture consisting of 6-amino-4-ethoxy-7-fluoro-1,4-benzoxazin -3(4H)-one (1.06 g), 1,2-cyclohexanedicarboxyaldehyde (0.7 g) and xylene (50 ml) was stirred for 15 minutes under heat-refluxing. After the solvent had been distilled off under reduced pressure, the residue was purified through silica-gel chromatography (eluent: hexane/ethyl acetate=19/1) to obtain the aimed 4-ethoxy-7-fluoro-6-(4,5,6,7-tetrahydroisoindole-2-yl)1,4-benzoxazin-3(4H)-one (1.37 g). nD20 1.5797

Provenance & Evidence