Sodium Methoxide → 2-Amino-4-methoxy-6-trifluoromethoxy-1,3,5-triazine

HRID 1742917Notes

Reaction equation

HRID 1742917 reaction equation
[CH3:1][O-:2].[Na+].[NH2:4][C:5]1[N:10]=[C:9](F)[N:8]=[C:7]([O:12][C:13]([F:16])([F:15])[F:14])[N:6]=1>CO>[NH2:4][C:5]1[N:10]=[C:9]([O:2][CH3:1])[N:8]=[C:7]([O:12][C:13]([F:16])([F:15])[F:14])[N:6]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 150103882-Amino-4-fluoro-6-trifluoromethoxy-1,3,5-triazin

Product 1

HCID 150103932-Amino-4-methoxy-6-trifluoromethoxy-1,3,5-triazine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
0 °C

Procedure

9.1 g (0.0505 mol) of 30% strength sodium methylate were added over the course of 15 minutes to a stirred mixture of 10 g (0.0505 mol ) of 2-amino-4-fluoro-6-trifluoromethoxy-1,3,5-triazine and 100 ml of methanol at 0° C. The mixture was stirred at 0° C. for one hour and then concentrated under reduced pressure, taken up in methylene chloride and extracted with water. Drying and concentration yielded 10.5 g (99% of theory) of the title compound of melting point 96°-101° C.

Workup

  1. concentrationconcentrated under reduced pressure
  2. extractionextracted with water
  3. customDrying
  4. concentrationconcentration

Sources & evidence

ORD record
ord-5d90e53328c24e84aeee16f269d51597
Source dataset
uspto-grants-1994_08
Patent number
US05342939

Reaction notes

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