Dimethylformamide → HCID 19006189, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 6-chloronicotinic acid (47.4 g, 0.3 mol) in xylene (150 ml) containing DMF (1.5 ml) was stirred and heated at 80° C. whilst SOCl2 (26.1 ml, 0.36 mol) was added during 20 minutes. Stirring and heating at 80° C. was continued for 11/2 hours, when all had passed into solution. Excess SOCl2, HCl, and a little xylene were then removed by distillation at 20 mm pressure. The residual solution was cooled to 40° C., and 2-hexyldecanol (72.9 g, 0.3 mol) was added during 20 minutes, the temperature rising to 55° C.

Provenance & Evidence