Hydrochloric Acid → HCID 86748093, compound

Participants

Reaction Steps

A mixture of 7-amino-4,9-dihydro-4-methyl-9-oxopyrazolo[5,1-b]quinazoline-2-carboxylic acid (8.03 g, 31.10 mmol, Example 1) in 600 mL of ethanol was saturated with hydrogen chloride gas for 20 minutes. The mixture was then refluxed for 12 hours, cooled, concentrated (to remove most of the ethanol), and partitioned between saturated sodium bicarbonate solution and chloroform (500 mL of each). Some solid would not dissolve into either phase. The mixture was filtered, giving 7.19 g (81%) of the title compound as a yellow solid, mp 258°-260° C., dec. The chloroform extract did contain more product, although not as clean.

Provenance & Evidence