1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 19006026, compound

Participants

Reaction Steps

To a suspension of 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (50 mg, 0.18 mmol) and 3-(1,2,3-triazol-1-yl)piperidine-1-yl hydrochloride (83 mg, 0.44 mmol) in 3 ml of acetonitrile was added 67 mg (0.44 mmol) of DBU. The solution was heated at reflux under nitrogen for 16 hrs. The suspension was cooled and the solid collected, washed with water, dried to yield 50 mg of the title product, m.p. 239°-240° C. 1H NMR (TFA) δ: 9.35 (s, 1H), 8.61 (s, 1H), 8.51 (s, 1H), 8.16 (d, J=10.6Hz, 1H), 5.45-5.15 (m, 1H), 4.7-3.55 (m, 5H), 2.85-2.05 (m, 4H), 1.8-1.3 (m, 4H).

Provenance & Evidence