Water → HCID 19005929, compound

Participants

Reaction Steps

A suspension of N-benzhydryl-3-[(methylsulfonyl)oxy]azetidine (0. 951 g, 3 mmol) and potassium-1,2,4-triazolide (0.69 g, 6.5 mmol) in 50 ml of dimethylformamide was heated at 85°-90° C. overnight. To this, water (200 ml) was added and extracted with ethyl acetate. The combined organic layers were washed with water, dried (Na2SO4) and evaporated to yield 0.9 g of the crude which upon purification over silica gel using ethyl acetate as solvent yielded 0.6 g of the desired product as a white solid. 1H NMR (CDCl3) δ: 8.22 (s, 1H), 7.97 (s, 1H), 7.57-7.12 (m, 5H), 5.13-4.9 (m, 1H), 4.53 (s, 1H), 3.8-3.4 (m, 4H).

Provenance & Evidence