1-Benzylpyrrolidin-3-yl methanesulfonate → HCID 19005960, compound

Participants

Reaction Steps

To a solution of 2.55 g (10 mmole) of N-benzyl-3-[(methyl-sulphonyl)oxy]pyrrolidine in 100 ml of dimethylformamide was added 3.21 g of potassium-1,2,4-triazolide and the reaction mixture was heated at 85°-90° C. overnight. The same work up and purification procedure described in Example U afforded 1.32 g (15% methanol-ethyl acetate as solvent) of the title product. 1H NMR (CDCl3) δ: 8.3 (S, 1H), 7.93 (S, 1H), 7.6-7.1 (m, 5H), 5.2-4.6 (m, 1H), 3.67 (S, 2H), 3.23-2 (m, 6H).

Provenance & Evidence