Hydrochloric Acid → HCID 19005973, compound

Participants

Reaction Steps

To a solution of N-benzyl-3-(5-ethoxy carbonyl -1,2,3-triazol-1-yl)pyrrolidine hydrochloride (2 g, 0.0061 mol) in methanol (100 ml) was added 10% Pd/C (200 mg) and concentrated HCl (1 ml). The suspension was hydrogenated at r.t. and 50 psi pressure for 20 hrs. The Pd/C was removed by filtration and the solution was concentrated. The residue was crystallized from methanol/ether to obtain crystalline white compound. Yield: 135 mg (93.29%). 1H NMR (D2O) δ: 1.42 (t, 3H), 2.52-2.86 (m, 2H), 3.65-3.75 (m, 2H), 3.87-4.08 (m, 2H), 3.47 (q, 2H), 5.58-5.69 (m, 1H), 8.69 (s, 1H).

Provenance & Evidence