Ethanol → HCID 54146711, compound

Participants

Reaction Steps

A solution of 0.3 g (1.8 mmole) of (R)-(+)-2-nitro-1-(2-oxiranylmethyl)-1H-imidazole, 0.24 g (5.4 mmole) of 1H-aziridine, and 3.5 mL of 99:1 absolute ethanol: triethylamine is heated at reflux for 10 minutes, cooled, and concentrated. The residue is crystallized from 99: 1 absolute ethanol:triethylamine to give 0.22 g of product, mp 118.5°-120° C. [α]D24 =+23.5° [c0.98, chloroform].

Provenance & Evidence