反应详情

A process for preparing (R)-(+)-α-[[2-bromoethyl)-amino]methyl]-2-nitro-1H-imidazole-1-ethanol, monohydrobromide which comprises reacting (S)-2-nitro-1-(2-oxiranylmethyl)-1H-imidazole with a 2-oxazolidinone of the formula ##STR15## in the presence of potassium trimethylsilanolate to give the (S)- enantiomer of a compound of the formula ##STR16## which is treated with hydrobromic acid in the presence of acetic acid.