HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2-oxo-3-phenylpropanoate → (3S,5S,6S)-3,6-dibenzyl-5-hydroxypiperidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2-oxo-3-phenylpropanoate | HCID 562359 | — |
| Reactant | L-Phenylalanine, methyl ester | HCID 736234 | — |
| Reactant | Methyl 3-methyl-2-oxobutanoate | HCID 12449855 | — |
| Product | (3S,5S,6S)-3,6-dibenzyl-5-hydroxypiperidin-2-one | HCID 57041890 | — |
Reaction Steps
Following the procedures outlined in Examples 2-6, and replacing L-cylohexylalanine methyl ester with L-phenylalanine methyl ester in Example 2 and methyl 3-methyl-2-oxobutyrate with methyl 3-phenyl-2-oxopropionate in Example 4 provides the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05342981 |
| Source dataset | uspto-grants-1994_08 |
| ORD ID | ord-e30f174db4a347a1a509a46170e82540 |
| Source note | uspto-grants-1994_08 |