Ethanol → HCID 69895285, compound

HRID 1743077Notes

Reaction equation

HRID 1743077 reaction equation
[I-].C(OC([NH:9][C@H:10]([C:25]([NH:27][CH2:28][CH2:29][CH2:30][N+:31]([CH3:34])([CH3:33])[CH3:32])=[O:26])[CH2:11][C:12]1[CH:17]=[CH:16][C:15]([N:18]([CH2:22][CH2:23][Cl:24])[CH2:19][CH2:20][Cl:21])=[CH:14][CH:13]=1)=O)(C)(C)C.C(O)C>CO>[ClH:21].[Cl:21][CH2:20][CH2:19][N:18]([CH2:22][CH2:23][Cl:24])[C:15]1[CH:14]=[CH:13][C:12]([CH2:11][C@@H:10]([C:25]([NH:27][CH2:28][CH2:29][CH2:30][N+:31]([CH3:33])([CH3:32])[CH3:34])=[O:26])[NH2:9])=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 702EthanolHCID 11966627HCID 11966627, compound

Product 1

HCID 69895285HCID 69895285, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

0.148 mmol of the product obtained in Step B is treated at ambient temperature for two ours with 10 ml of 2N hydrochloric ethanol. The solution is then evaporated under reduced pressure. The residue obtained is dissolved in 50 ml of methanol and passed over resin for a few minutes. The methanolic fractions are evaporated off under reduced pressure. The residue obtained is taken up in the minimum amount of methanol and poured into an ethereal solution. The expected product is isolated in the form of a very hydroscopic white-beige solid by means of filtration, washing with ether and drying.

Workup

  1. customThe solution is then evaporated under reduced pressure
  2. customThe residue obtained
  3. waitpassed over resin for a few minutes
  4. customThe methanolic fractions are evaporated off under reduced pressure
  5. customThe residue obtained
  6. additionpoured into an ethereal solution

Sources & evidence

ORD record
ord-77efc267f4b94b1d84491dfc1f752525
Source dataset
uspto-grants-2006_03
Patent number
US07008613B2

Reaction notes

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