N,N-Dimethyl-1,3-propanediamine → HCID 22238168, compound

Participants

Reaction Steps

Using an analogous procedure to that described in the sixth paragraph of the portion of Note a) immediately above which is concerned with the preparation of starting materials. 4-chloro-3-(5-chloro-2-nitrobenzamido)-N-(3-fluoro-5-morpholinophenyl)benzamide was reacted with 3-dimethylaminopropylamine to give 4-chloro-3-[5-(3-dimethylaminopropylamino)-2-nitrobenzamido]-N-(3-fluoro-5-morpholinophenyl)benzamide in 76% yield; NMR Spectrum: (DMSOd6) 1.62–1.74 (m, 2H), 2.12 (s, 6H), 2.27 (t, 2H), 3.08–3.13 (m, 4H), 3.18–3.22 (m, 2H), 3.69–3.74 (m, 4H), 6.58 (d, 1H) 6.67 (m, 2H), 7.15–7.2 (m, 2H), 7.42 (t, 1H), 7.69 (d, 1H), 7.68 (d, 1H), 7.82 (d, 1H), 8.04 (d, 1H), 8.26 (s, 1H), 10.32 (s, 1H); Mass Spectrum: M+H+ 599.

Provenance & Evidence