2-Chloropyridine-4-carbonyl chloride → HCID 22238155, compound

Participants

Reaction Steps

Using an analogous procedure to that described in Example 5, 3-(5-amino-2-methylphenyl)-6-(4-methylhomopiperazin-1-yl)-3,4-dihydroquinazolin-4-one was reacted with 2-chloropyridine-4-carbonyl chloride to give the title compound; NMR Spectrum: (DMSOd6) 1.84–1.96 (m, 2H), 2.06 (s, 3H), 2.29 (s, 3H), 2.42–2.49 (m, 2H), 2.62–2.68 (m, 2H), 3.53 (t, 2H), 3.58–3.64 (m, 2H), 7.22 (d, 1H), 7.34 (m, 1H), 7.44 (m, 1H), 7.58 (d, 1H), 7.73–7.78 (m, 2H), 7.82–7.86 (m, 1H), 7.96–7.98 (m, 2H), 8.50–8.62 (m, 1H), 10.68 (s, 1H); Mass Spectrum: M+H+ 503 & 505.

Provenance & Evidence