HCID 22238484, compound → HCID 22238489, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-(4-amino-5-iodo-2-methoxyphenyl)oxazole (WO 0181340) (0.293 g, 0.93 mmol) in diethylamine (2.5 mL) was added 4-ethynylthiazole (0.118 g, 1.08 mmol) and bis(triphenylphosphine)palladiumdichloride (0.019 g, 0.027 mmol). The contents were purged with nitrogen and heated in a steel bomb at 120° C. for 20 minutes. The reaction mixture was cooled to rt and purified by silica gel column chromatography to provide the title compound (0.065 g, 20%). HPLC Ret. t=2.79 min. (A); LC/MS M+1=298.27.

Provenance & Evidence