Benzenamine, 2-phenoxy- → HCID 9969484, compound

HRID 1743141Notes

Reaction equation

HRID 1743141 reaction equation
C([O:3][C:4]1[C:5](=[O:17])[C:6](=O)[C:7]=1[NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[OH:15])C.[O:18]([C:25]1[CH:31]=[CH:30][CH:29]=[CH:28][C:26]=1[NH2:27])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>CS(C)=O>[O:18]([C:25]1[CH:31]=[CH:30][CH:29]=[CH:28][C:26]=1[NH:27][C:6]1[C:5](=[O:17])[C:4](=[O:3])[C:7]=1[NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[OH:15])[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

4

Reactant 2

HCID 75899Benzenamine, 2-phenoxy-HCID 28266183-Ethoxy-4-(2-hydroxyanilino)cyclobut-3-ene-1,2-dione

Product 1

HCID 9969484HCID 9969484, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
110 °C

Procedure

To a solution of 3-ethoxy-4-(2-hydroxyanilino)-cyclobut-3-ene-1,2-dione (50 mg, 0.21 mmol) in DMSO (1.5 mL) was added 2-penoxyaniline (49 mg, 0.21 mmol) and reaction was stirred at 110° C. overnight. Reaction was purified on HPLC (acetonitrile:water) and product was concentrated down. Solid was dried in vacuo. LC-MS (m/z) 373 (M+).

Workup

  1. customReaction
  2. customwas purified on HPLC (acetonitrile:water) and product
  3. concentrationwas concentrated down
  4. customSolid was dried in vacuo

Sources & evidence

ORD record
ord-dbb023a6b9be422a9f57d5e20bf7b841
Source dataset
uspto-grants-2006_03
Patent number
US07008962B2

Reaction notes

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