HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1743147Generated: October 27, 2026
3-Chloro-2-methylaniline → 3-(3-Chloro-2-methylanilino)-4-(2-hydroxyanilino)-cyclobut-3-ene-1,2-dione
https://huagongshe.com/reaction/1743147
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Chloro-2-methylaniline | HCID 6894 | — |
| Reactant | 3-Ethoxy-4-(2-hydroxyanilino)cyclobut-3-ene-1,2-dione | HCID 2826618 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 3-(3-Chloro-2-methylanilino)-4-(2-hydroxyanilino)-cyclobut-3-ene-1,2-dione | HCID 9967234 | — |
Reaction Steps
To a solution of 3-ethoxy-4-(2-hydroxyanilino)-cyclobut-3-ene-1,2-dione (50 mg, 0.21 mmol) in DMSO (1.5 mL) was added 3-chloro-2-methylaniline (0.026 mL, 0.21 mmol) and reaction was stirred at 110° C. overnight. Reaction was purified on HPLC (acetonitrile:water) and product was concentrated down. Solid was dried in vacuo. LC-MS (m/z) 329 (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07008962B2 |
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| Source dataset | uspto-grants-2006_03 |
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| ORD ID | ord-0af45d0dc22448f3b0274975816e201f |
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| Source note | uspto-grants-2006_03 |
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