HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl squarate → 3-Ethoxy-4-(2-hydroxy-4-cyanoanilino)-3-cyclobutene-1,2-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl squarate | HCID 123228 | — |
| Reactant | 4-Amino-3-hydroxybenzonitrile | HCID 10197719 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Ethoxy-4-(2-hydroxy-4-cyanoanilino)-3-cyclobutene-1,2-dione | HCID 10515337 | 53.5% |
Reaction Steps
A solution of 3,4-diethoxy-3-cyclobutene-1,2-dione (1.2 mL, 8.12 mmol) and 3-hydroxy-4-aminobenzonitrile (1.25 g, 8.11 mmol) in ethanol was heated at 85° C. for overnight. A tan precipitates forms. The solid was filtered, and collected. 1.12 g (53%) of 3-ethoxy-4-(2-hydroxy-4-cyanoanilino)-3-cyclobutene-1,2-dione was obtained. LC/MS(H+) 259
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07008962B2 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-43f187c7d38f490fb40c6e015b4bef71 |
| Source note | uspto-grants-2006_03 |