4-Methyloxybenzyl chloride → 3-(4-Isopropylphenyl)-5-(4-methoxybenzyloxy)-2,2-dimethyl-2,3-dihydrobenzofuran

HRID 1743209Notes

Reaction equation

HRID 1743209 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]2[C:14]3[CH:15]=[C:16]([OH:19])[CH:17]=[CH:18][C:13]=3[O:12][C:11]2([CH3:21])[CH3:20])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[CH3:22][O:23][C:24]1[CH:31]=[CH:30][C:27]([CH2:28]Cl)=[CH:26][CH:25]=1>>[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([CH:10]2[C:14]3[CH:15]=[C:16]([O:19][CH2:28][C:27]4[CH:30]=[CH:31][C:24]([O:23][CH3:22])=[CH:25][CH:26]=4)[CH:17]=[CH:18][C:13]=3[O:12][C:11]2([CH3:21])[CH3:20])=[CH:8][CH:9]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 699934-Methyloxybenzyl chlorideHCID 22238263(4-Isopropylphenyl)-2,2-dimethyl-2,3-dihydrobenzofuran-5-ol

Product 1

HCID 222382673-(4-Isopropylphenyl)-5-(4-methoxybenzyloxy)-2,2-dimethyl-2,3-dihydrobenzofuranYield 75%

Procedure

Using (4-isopropylphenyl)-2,2-dimethyl-2,3-dihydrobenzofuran-5-ol and 4-methoxybenzyl chloride, the title compound was obtained in the same manner as in Example 1.

Sources & evidence

ORD record
ord-d440b8f03f6a4763a77625f59c39bb41
Source dataset
uspto-grants-2006_03
Patent number
US07008950B1

Reaction notes

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